Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | TACR3 | P29371 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202930 | 0.80 | SLC2A1 (0.59) | LMNAMAPTHTTALDH1A1POLB | |
| SCHEMBL5204486 | 0.80 | MAPT (0.54) | LMNAMAPTHTTALDH1A1RAB9A | |
| SCHEMBL5705162 | 0.75 | RORC (0.51) | LMNAALDH1A1POLBHPGDTPSAB1 | |
| SCHEMBL5937364 | 0.75 | ALDH1A1 (0.57) | LMNAMAPTALDH1A1POLBTPSAB1 | |
| SCHEMBL4858050 | 0.74 | RAB9A (0.62) | LMNAMAPTALDH1A1POLBRAB9A | |
| SCHEMBL4859112 | 0.74 | RORC (0.47) | LMNAMAPTALDH1A1POLBHTR6 | |
| SCHEMBL5202338 | 0.74 | GFER (0.47) | ALDH1A1POLBRAB9AHTR6GFER | |
| SCHEMBL4855807 | 0.74 | KDM4E (0.48) | LMNAMAPK1ALDH1A1NPSR1TPSAB1 | |
| SCHEMBL4859672 | 0.73 | HSD11B1 (0.52) | POLBGFERTPSAB1HSD11B1 | |
| SCHEMBL5201722 | 0.73 | HTR2B (0.53) | LMNAMAPK1ALDH1A1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |