Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 6/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3919528 | 0.96 | PGR (0.53) | PGRHTTSMN1; SMN2NCOA1NCOA3 | |
| SCHEMBL6583356 | 0.92 | SETD7 (0.52) | PGRSMN1; SMN2ALDH1A1POLBMAPT | |
| SCHEMBL5203350 | 0.90 | PGR (0.63) | PGRHTTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL6583496 | 0.90 | SETD7 (0.51) | PGRHTTALDH1A1LMNAPOLB | |
| SCHEMBL6582141 | 0.90 | SETD7 (0.51) | PGRHTTSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL6581955 | 0.89 | SETD7 (0.52) | PGRHTTSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL6583352 | 0.88 | PGR (0.50) | PGRSMN1; SMN2ALDH1A1LMNANPSR1 | |
| SCHEMBL6584768 | 0.87 | KMT2A (0.49) | PGRHTTSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL6579233 | 0.86 | PGR (0.49) | PGRSMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL5202716 | 0.86 | ALDH1A1 (0.49) | PGRSMN1; SMN2ALDH1A1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087946-B1 | ARYL ALKANOYLPYRIDAZINES | MERCK PATENT GMBH (DE) | 2007-01-10 | — | — | EP | disclosed |
| US-6417188-B1 | ENZYME INHIBITORS OF PHOSPHODIESTERASE | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-07-09 | — | — | US | disclosed |