Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL5202990

NCc1cccc(Oc2ccccc2N(Cc2ccc(-c3cc(Cl)ccc3Cl)cc2)C(=O)CCC(=O)NCc2ccccc2C(F)(F)F)c1.O=C(O)C(F)(F)F

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
P2RX4 Q99571 1/20 0.39
EPHX2 P34913 3/20 0.33
MAP2K7 O14733 1/20 0.33
MMEL1 Q495T6 1/20 0.33
ALDH1A1 P00352 1/20 0.33
ATM Q13315 1/20 0.33
TAOK1 Q7L7X3 1/20 0.33
TAOK3 Q9H2K8 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
PLA2G1B P04054 1/20 0.33
HTT P42858 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
ATG4B Q9Y4P1 1/20 0.33
LMNA P02545 1/20 0.33
GCGR P47871 1/20 0.32
LTB4R2 Q9NPC1 1/20 0.32
TPSAB1 Q15661 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL5204301 0.94 AHCY (0.37) P2RX4MMEL1ALDH1A1SMN1; SMN2PLA2G1B
Trifluoroacetic Acid SCHEMBL5202498 0.90 EPHX2 (0.38) P2RX4EPHX2MAP2K7ALDH1A1HTT
Trifluoroacetic Acid SCHEMBL5205650 0.89 TAOK1 (0.38) P2RX4EPHX2MAP2K7ALDH1A1TAOK1
Trifluoroacetic Acid SCHEMBL5205759 0.89 TAOK1 (0.36) EPHX2ALDH1A1TAOK1TAOK3SMN1; SMN2
Trifluoroacetic Acid SCHEMBL5202054 0.88 TSPO (0.39) EPHX2TPSAB1
Trifluoroacetic Acid SCHEMBL5205038 0.88 SUCNR1 (0.36) P2RX4EPHX2MAP2K7TAOK1TAOK3
Trifluoroacetic Acid SCHEMBL5205396 0.87 TSPO (0.41) EPHX2ALDH1A1TAOK1TAOK3HTT
Trifluoroacetic Acid SCHEMBL5208369 0.86 BACE1 (0.45) EPHX2TAOK1TAOK3LTB4R2TPSAB1
Trifluoroacetic Acid SCHEMBL5204263 0.86 HDAC1 (0.37) EPHX2MAP2K7TAOK1TAOK3L3MBTL1
Trifluoroacetic Acid SCHEMBL5208213 0.86 TAOK1 (0.37) EPHX2ALDH1A1TAOK1TAOK3HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7160887-B1 Aromatic amine derivatives, their production and use TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-01-09 US disclosed
EP-1123918-B1 AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME TAKEDA PHARMACEUTICAL (JP) 2005-03-09 EP disclosed
EP-1123918-A1 AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME Takeda Chemical Industries, Ltd. (JP) 2001-08-16 EP disclosed