SCHEMBL5203024

SCHEMBL5203024

CSc1nc(OCc2ccc(F)cc2F)cc(=O)n1CC(C)(C)C

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.37
MAPK14 Q16539 12/20 0.36
HTR2A P28223 1/20 0.36
HTR2C P28335 1/20 0.36
SLC6A4 P31645 1/20 0.36
KDM4E B2RXH2 1/20 0.35
ALDH1A1 P00352 1/20 0.35
GAA P10253 1/20 0.35
MAPT P10636 1/20 0.35
HPGD P15428 1/20 0.35
IDO1 P14902 1/20 0.35
AGXT P21549 1/20 0.35
MAPKAPK2 P49137 1/20 0.35
PTGER1 P34995 1/20 0.34
CYP1A1 P04798 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP1B1 Q16678 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5207452 0.85 MEN1 (0.39) MAOBMAPK14IDO1AGXTPTGER1
SCHEMBL5280738 0.83 MCHR1 (0.42) MAOBMAPK14IDO1AGXT
SCHEMBL5205590 0.81 MAOB (0.39) MAOBMAPK14IDO1AGXTPTGER1
SCHEMBL5203025 0.79 HTR2A (0.38) MAOBMAPK14HTR2AHTR2CSLC6A4
SCHEMBL5241613 0.79 MAPK14 (0.45) MAPK14MAPKAPK2
SCHEMBL3526249 0.72 MAPK14 (0.49) MAOBMAPK14PTGER1
SCHEMBL3523048 0.72 MAPK14 (0.39) MAOBMAPK14PTGER1
SCHEMBL5207326 0.71 MAOB (0.38) MAOBMAPK14IDO1AGXTPTGER1
SCHEMBL3521563 0.71 MAPK14 (0.55) MAOBMAPK14
SCHEMBL3524686 0.69 MAPK14 (0.46) MAOBMAPK14ALDH1A1HPGDCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1802590-A1 SUBSTITUTED N-ALKYLPYRIMIDINONES Pharmacia & Upjohn Company LLC (US) 2007-07-04 EP disclosed
WO-2006040666-A1 SUBSTITUTED N-ALKYLPYRIMIDINONES PHARMACIA & UPJOHN COMPANY LLC (US) 2006-04-20 WO disclosed