Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203345 | 0.81 | HDAC1 (0.43) | TOP2ALTA4HKDM4EMAPTPDE5A | |
| SCHEMBL7249558 | 0.71 | CYP4F2 (0.55) | — | |
| SCHEMBL27344292 | 0.70 | TOP2A (0.55) | TOP2ACYP3A4CYP2D6CYP2C19LTA4H | |
| SCHEMBL5202185 | 0.69 | NR4A2 (0.39) | L3MBTL1ALDH1A1LMNA | |
| SCHEMBL27571929 | 0.69 | ALDH1A1 (0.41) | CYP3A4CYP2C19KDM4EMAPTL3MBTL1 | |
| SCHEMBL13125414 | 0.69 | SMN1; SMN2 (0.58) | TOP2ACYP3A4CYP2D6CYP2C19LTA4H | |
| SCHEMBL2498217 | 0.68 | TOP2A (0.56) | TOP2ACYP3A4CYP2D6CYP2C19LTA4H | |
| SCHEMBL5208051 | 0.68 | MEN1 (0.41) | CYP3A4CYP2D6CYP2C19KDM4EMAPT | |
| SCHEMBL27590289 | 0.68 | KDM4E (0.41) | KDM4EMAPTL3MBTL1ALDH1A1LMNA | |
| SCHEMBL7301777 | 0.68 | TOP2A (0.53) | TOP2ACYP3A4CYP2D6CYP2C19LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7160887-B1 | Aromatic amine derivatives, their production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-09 | — | — | US | disclosed |
| EP-1123918-B1 | AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME | TAKEDA PHARMACEUTICAL (JP) | 2005-03-09 | — | — | EP | disclosed |
| EP-1123918-A1 | AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME | Takeda Chemical Industries, Ltd. (JP) | 2001-08-16 | — | — | EP | disclosed |