Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 4/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.41 |
| ▸ | PPID | Q08752 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201771 | 0.85 | NAMPT (0.47) | HDAC1TOP2ALTA4HNAMPTCA1 | |
| SCHEMBL5203338 | 0.81 | TOP2A (0.40) | TOP2ALTA4HPDE5AELANEKDM4E | |
| SCHEMBL5205312 | 0.80 | PPARG (0.40) | TOP2AALOX15KDM4EMAPT | |
| SCHEMBL5202903 | 0.77 | PPARG (0.40) | FAAHALOX15 | |
| SCHEMBL6376720 | 0.74 | CYP4F2 (0.56) | NAMPTCA1CA2PPIDMAPT | |
| SCHEMBL5205300 | 0.74 | PPARG (0.41) | ALOX15KDM4E | |
| SCHEMBL5202388 | 0.74 | CNR1 (0.40) | HDAC1KDM4EMAPT | |
| SCHEMBL16456594 | 0.74 | FAAH (0.56) | HDAC1NAMPTFAAH | |
| SCHEMBL7254343 | 0.73 | ALDH1A1 (0.46) | TOP2ALTA4HNAMPT | |
| SCHEMBL8786889 | 0.72 | MAPT (0.51) | NAMPTCA1CA2PPIDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7160887-B1 | Aromatic amine derivatives, their production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-09 | — | — | US | disclosed |
| EP-1123918-B1 | AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME | TAKEDA PHARMACEUTICAL (JP) | 2005-03-09 | — | — | EP | disclosed |
| EP-1123918-A1 | AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME | Takeda Chemical Industries, Ltd. (JP) | 2001-08-16 | — | — | EP | disclosed |