Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 7/20 | 0.48 |
| ▸ | DRD2 | P14416 | 6/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.48 |
| ▸ | HRH2 | P25021 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8280705 | 0.87 | DRD3 (0.58) | DRD3DRD2ADRA2AHRH2DRD4 | |
| SCHEMBL11241158 | 0.82 | DRD2 (0.45) | DRD3DRD2ADRA2AHRH2DRD4 | |
| SCHEMBL17481210 | 0.81 | NOS3 (0.37) | DRD3DRD2ADRA2AHRH2DRD4 | |
| SCHEMBL5204000 | 0.77 | APOBEC3A (0.48) | DRD3DRD2ADRA2AHRH2DRD4 | |
| SCHEMBL5810245 | 0.74 | DRD2 (0.59) | DRD3DRD2ADRA2AHRH2DRD4 | |
| SCHEMBL5810238 | 0.74 | DRD2 (0.59) | DRD3DRD2ADRA2AHRH2DRD4 | |
| SCHEMBL5810241 | 0.74 | DRD2 (0.59) | DRD3DRD2ADRA2AHRH2DRD4 | |
| SCHEMBL14492240 | 0.74 | DRD3 (0.80) | DRD3DRD2ADRA2AHRH2DRD4 | |
| Hydrochloric Acid SCHEMBL7315225 | 0.73 | DRD3 (0.51) | DRD3DRD2ADRA2AHRH2DRD4 | |
| Hydrochloric Acid SCHEMBL5809870 | 0.73 | ADRA2A (0.60) | DRD3DRD2ADRA2AHRH2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343561-B1 | SERINE PROTEASE INHIBITORS | TULARIK LTD (GB) | 2007-02-28 | — | — | EP | disclosed |
| EP-1343561-A1 | SERINE PROTEASE INHIBITORS | Tularik Limited (GB) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002047762-A1 | SERINE PROTEASE INHIBITORS | TULARIK LIMITED (GB) | 2002-06-20 | — | — | WO | disclosed |