Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.43 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202048 | 0.94 | SLC2A1 (0.44) | HSD11B1HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL5201977 | 0.88 | SLC2A1 (0.46) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL5202510 | 0.85 | HSD11B1 (0.55) | HSD11B1KMT2AALDH1A1SMN1; SMN2CYP2C9 | |
| SCHEMBL5204138 | 0.85 | MGLL (0.49) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL4862016 | 0.84 | SLC5A1 (0.49) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL5204227 | 0.83 | SLC2A1 (0.46) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL4853030 | 0.83 | HDAC3 (0.46) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL4857565 | 0.82 | HDAC3 (0.46) | HSD11B1HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL5202509 | 0.81 | SLC2A1 (0.49) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL5203686 | 0.81 | SLC5A1 (0.49) | HSD11B1HDAC3HDAC1HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |