Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A1 | P13866 | 1/20 | 0.49 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | ICMT | O60725 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5204138 | 0.89 | MGLL (0.49) | SLC2A1HRH3HDAC3HDAC1HDAC2 | |
| SCHEMBL4862016 | 0.86 | SLC5A1 (0.49) | SLC5A1SLC5A2SLC2A1HRH3HDAC3 | |
| SCHEMBL4853030 | 0.86 | HDAC3 (0.46) | SLC5A1SLC5A2SLC2A1HRH3HDAC3 | |
| SCHEMBL5204227 | 0.85 | SLC2A1 (0.46) | SLC2A1HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL5204533 | 0.85 | ALDH1A1 (0.46) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL3598394 | 0.84 | SIGMAR1 (0.57) | SLC2A1HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL4857565 | 0.84 | HDAC3 (0.46) | SLC5A1SLC5A2SLC2A1HDAC3HDAC1 | |
| SCHEMBL3605157 | 0.83 | SLC2A1 (0.53) | SLC5A1SLC5A2SLC2A1HDAC3HDAC1 | |
| SCHEMBL4860077 | 0.81 | SLC2A1 (0.45) | SLC5A1SLC5A2SLC2A1HRH3HDAC3 | |
| SCHEMBL5204238 | 0.81 | HSD11B1 (0.47) | SLC5A1SLC5A2SLC2A1HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |