Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 6/20 | 0.47 |
| ▸ | ITGA5 | P08648 | 6/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 14/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 10/20 | 0.46 |
| ▸ | ITGAV | P06756 | 9/20 | 0.46 |
| ▸ | MDM4 | O15151 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5204669 | 0.90 | ITGB1 (0.49) | ITGB1ITGA5ITGB3ITGA2BITGAV | |
| SCHEMBL6496052 | 0.90 | ITGB1 (0.47) | ITGB1ITGA5ITGB3ITGA2BITGAV | |
| SCHEMBL6494288 | 0.88 | ITGB3 (0.52) | ITGB1ITGA5ITGB3ITGA2BITGAV | |
| SCHEMBL3039366 | 0.86 | ITGB3 (0.40) | ITGB3ITGA2BITGAVALOX15CHRM2 | |
| SCHEMBL3041592 | 0.86 | ITGB3 (0.53) | ITGB1ITGA5ITGB3ITGA2BITGAV | |
| SCHEMBL13170303 | 0.84 | ITGB1 (0.51) | ITGB1ITGA5ITGB3ITGA2BITGAV | |
| SCHEMBL6495002 | 0.83 | ITGB3 (0.41) | ITGB1ITGA5ITGB3ITGA2BITGAV | |
| SCHEMBL13170301 | 0.82 | ITGB1 (0.53) | ITGB1ITGA5ITGB3ITGA2BITGAV | |
| SCHEMBL3048694 | 0.80 | ITGB1 (0.50) | ITGB1ITGA5ITGB3ITGA2BITGAV | |
| SCHEMBL14431255 | 0.80 | ITGB1 (0.50) | ITGB1ITGA5ITGB3ITGA2BITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124824-B1 | CHROMENONE AND CHROMANONE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2007-08-22 | — | — | EP | claimed |
| US-7803399-B2 | Delivery system for nucleic acids | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-09-28 | — | — | US | disclosed |
| EP-1124824-B1 | CHROMENONE AND CHROMANONE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2007-08-22 | — | — | EP | disclosed |
| US-6849646-B1 | Chromenone and chromanone derivatives as integrin inhibitors | MERCK PATENT GMBH (DE) | 2005-02-01 | — | — | US | disclosed |
| EP-1124824-A1 | CHROMENONE AND CHROMANONE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GmbH (DE) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026212-A1 | CHROMENONE AND CHROMANONE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2000-05-11 | — | — | WO | disclosed |