Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 13/20 | 0.52 |
| ▸ | ITGAV | P06756 | 12/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.52 |
| ▸ | ITGB1 | P05556 | 6/20 | 0.50 |
| ▸ | ITGA5 | P08648 | 6/20 | 0.50 |
| ▸ | MDM4 | O15151 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5204669 | 0.91 | ITGB1 (0.49) | ITGB3ITGAVITGA2BITGB1ITGA5 | |
| SCHEMBL3041592 | 0.89 | ITGB3 (0.53) | ITGB3ITGAVITGA2BITGB1ITGA5 | |
| SCHEMBL6496052 | 0.88 | ITGB1 (0.47) | ITGB3ITGAVITGA2BITGB1ITGA5 | |
| SCHEMBL5204428 | 0.88 | ITGB1 (0.47) | ITGB3ITGAVITGA2BITGB1ITGA5 | |
| SCHEMBL13170303 | 0.87 | ITGB1 (0.51) | ITGB3ITGAVITGA2BITGB1ITGA5 | |
| SCHEMBL6505728 | 0.87 | ITGB3 (0.49) | ITGB3ITGAVITGA2BMMP2ADAMTS4 | |
| SCHEMBL13170301 | 0.85 | ITGB1 (0.53) | ITGB3ITGAVITGA2BITGB1ITGA5 | |
| SCHEMBL13170302 | 0.83 | ITGB1 (0.49) | ITGB3ITGAVITGA2BITGB1ITGA5 | |
| SCHEMBL6503005 | 0.82 | ITGB3 (0.51) | ITGB3ITGAVITGA2BITGB1ITGA5 | |
| SCHEMBL3048694 | 0.82 | ITGB1 (0.50) | ITGB3ITGAVITGA2BITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849646-B1 | Chromenone and chromanone derivatives as integrin inhibitors | MERCK PATENT GMBH (DE) | 2005-02-01 | — | — | US | disclosed |