Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5205858 | 1.00 | ELANE (0.45) | ELANETRPV1MAOAMAOBSMN1; SMN2 | |
| SCHEMBL5202964 | 0.84 | NPC1 (0.50) | ELANEMAOBSMN1; SMN2PARP1LMNA | |
| SCHEMBL18327182 | 0.84 | NPC1 (0.50) | ELANEMAOBSMN1; SMN2PARP1LMNA | |
| SCHEMBL5204611 | 0.84 | NPC1 (0.50) | ELANEMAOBSMN1; SMN2PARP1LMNA | |
| SCHEMBL5206016 | 0.82 | LMNA (0.52) | ELANEMAOBSMN1; SMN2PARP1KMT2A | |
| SCHEMBL5206138 | 0.82 | LMNA (0.52) | ELANEMAOBSMN1; SMN2PARP1KMT2A | |
| SCHEMBL5204972 | 0.81 | SMN1; SMN2 (0.50) | MAOAMAOBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5201729 | 0.81 | SMN1; SMN2 (0.50) | MAOAMAOBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5203413 | 0.81 | NPC1 (0.53) | ELANESMN1; SMN2PARP1KMT2AMEN1 | |
| SCHEMBL5203419 | 0.81 | NPC1 (0.53) | ELANESMN1; SMN2PARP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458706-B1 | DIARYL 1,2,4-TRIAZOLE DERIVATIVES AS A HIGHLY SELECTIVE CYCLOOXYGENASE-2 INHIBITOR | CJ CORP (KR) | 2007-07-11 | — | — | EP | disclosed |
| US-7169929-B2 | Diaryl 1,2,4-triazole derivatives as a highly selective cyclooxygenase-2 inhibitor | CJ CORP. (KR) | 2007-01-30 | — | — | US | disclosed |
| US-7135572-B2 | Diaryl 1,2,4-triazole derivatives as a highly selective cyclooxygenase-2 inhibitor | CJ CORP (KR) | 2006-11-14 | — | — | US | disclosed |
| US-20060009495-A1 | Diary 1,2,4-triazole derivatives as a highly selective cyclooxygenase-2 inhibitor | CJ CORP. (KR) | 2006-01-12 | — | — | US | disclosed |
| EP-1458706-A4 | DIARYL 1,2,4-TRIAZOLE DERIVATIVES AS A HIGHLY SELECTIVE CYCLOOXYGENASE-2 INHIBITOR | CJ CORP (KR) | 2005-06-08 | — | — | EP | disclosed |
| US-20050075373-A1 | Diaryl 1,2,4-triazole derivatives as a highly selective cyclooxygenase-2 inhibitor | CJ CORP. (KR) | 2005-04-07 | — | — | US | disclosed |
| EP-1458706-A1 | DIARYL 1,2,4-TRIAZOLE DERIVATIVES AS A HIGHLY SELECTIVE CYCLOOXYGENASE-2 INHIBITOR | CJ Corp. (KR) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003055875-A1 | DIARYL 1,2,4-TRIAZOLE DERIVATIVES AS A HIGHLY SELECTIVE CYCLOOXYGENASE-2 INHIBITOR | CJ CORP. (KR) | 2003-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060009495-A1 | Diary 1,2,4-triazole derivatives as a highly selective cyclooxygenase-2 inhibitor | PTGS1, PTGS2, PTGES2 | ELANE 2525/4885TRPV1 551/4885MAOA 379/4885 |
| US-20050075373-A1 | Diaryl 1,2,4-triazole derivatives as a highly selective cyclooxygenase-2 inhibitor | PTGS1, PTGS2, PTGES2 | ELANE 2701/4885TRPV1 301/4885MAOA 304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.