Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2112323 | 0.98 | LMNA (0.68) | LMNACYP3A4CYP2C19KDM4EALDH1A1 | |
| SCHEMBL10002472 | 0.97 | LMNA (0.60) | LMNACYP3A4CYP2C19KDM4EALDH1A1 | |
| SCHEMBL1480336 | 0.93 | LMNA (0.55) | LMNACYP3A4CYP2C19KDM4EALDH1A1 | |
| SCHEMBL2701584 | 0.85 | ALDH1A1 (0.59) | LMNACYP3A4CYP2C19ALDH1A1MAPT | |
| SCHEMBL7293343 | 0.85 | ALDH1A1 (0.80) | LMNACYP3A4CYP2C19KDM4EALDH1A1 | |
| SCHEMBL13692378 | 0.84 | CYP3A4 (0.58) | LMNACYP3A4CYP2C19KDM4EALDH1A1 | |
| SCHEMBL503291 | 0.84 | KMT2A (0.65) | LMNACYP3A4CYP2C19KDM4EALDH1A1 | |
| SCHEMBL21874269 | 0.83 | KMT2A (0.63) | LMNACYP3A4CYP2C19KDM4EALDH1A1 | |
| SCHEMBL8586765 | 0.83 | KDM4E (0.58) | LMNACYP3A4CYP2C19KDM4EALDH1A1 | |
| SCHEMBL15256583 | 0.83 | CYP3A4 (0.57) | LMNACYP3A4CYP2C19KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490043-A4 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO INC (US) | 2007-05-30 | — | — | EP | claimed |
| EP-1490043-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2004-12-29 | — | — | EP | claimed |
| WO-2003082190-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-10-09 | — | — | WO | claimed |