Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | ATF4 | P18848 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | GPR183 | P32249 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4859500 | 0.87 | KMT2A (0.52) | MAPTALDH1A1SMN1; SMN2GAARAB9A | |
| SCHEMBL5205873 | 0.85 | HRH2 (0.51) | MAPTALDH1A1SMN1; SMN2GAARAB9A | |
| SCHEMBL5203803 | 0.79 | MAPT (0.52) | MAPTALDH1A1SMN1; SMN2GAARAB9A | |
| SCHEMBL5206944 | 0.74 | RAB9A (0.55) | MAPTALDH1A1SMN1; SMN2GAARAB9A | |
| SCHEMBL5818040 | 0.74 | SLC2A1 (0.47) | MAPTALDH1A1SMN1; SMN2GAARAB9A | |
| SCHEMBL5203557 | 0.73 | ALDH1A1 (0.50) | ALDH1A1GAARAB9AL3MBTL1HRH2 | |
| SCHEMBL5203814 | 0.71 | SMO (0.51) | MAPTALDH1A1CYP3A4HTTPOLB | |
| SCHEMBL5204486 | 0.70 | MAPT (0.54) | MAPTALDH1A1SMN1; SMN2RAB9AHTT | |
| SCHEMBL5203232 | 0.69 | LMNA (0.51) | MAPTALDH1A1RAB9AHTTPOLB | |
| SCHEMBL5202233 | 0.69 | HRH2 (0.41) | MAPTALDH1A1RAB9APOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |