Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 5/20 | 0.40 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203622 | 0.88 | SLC2A1 (0.46) | HRH2HTR2AHTR2CHTR2BMEN1 | |
| SCHEMBL5238287 | 0.79 | SLC2A1 (0.41) | HRH2HTR2AHTR2CHTR2BCNR2 | |
| SCHEMBL5204952 | 0.75 | HRH2 (0.55) | HRH2HTR2AHTR2CHTR2BCNR2 | |
| SCHEMBL5205873 | 0.74 | HRH2 (0.51) | HRH2HTR2AHTR2CHTR2BCNR2 | |
| SCHEMBL5205803 | 0.73 | HRH2 (0.50) | HRH2HTR2AHTR2CHTR2BCNR2 | |
| SCHEMBL5203433 | 0.73 | TPSAB1 (0.50) | HRH2HTR2AHTR2CHTR2BCNR2 | |
| SCHEMBL4849757 | 0.72 | HRH2 (0.47) | HRH2HTR2AHTR2CHTR2BCNR2 | |
| SCHEMBL5201671 | 0.70 | ALDH1A1 (0.51) | HRH2HTR2AHTR2CHTR2BCNR2 | |
| SCHEMBL4859740 | 0.69 | HTR2A (0.46) | HRH2HTR2AHTR2CHTR2BCNR2 | |
| SCHEMBL27559062 | 0.69 | HRH2 (0.59) | HRH2HTR2AHTR2CHTR2BCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |