Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.55 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 5/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | FRK | P42685 | 1/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | PTAFR | P25105 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200991 | 0.84 | HRH1 (0.46) | HRH1DRD2HTR2AKDRCSF1R | |
| SCHEMBL5206195 | 0.80 | BRAF (0.62) | CSF1RBRAF | |
| SCHEMBL4317692 | 0.76 | TAAR1 (0.48) | HRH1DRD2HTR2ACSF1RBRAF | |
| SCHEMBL4311625 | 0.76 | FYN (0.47) | HRH1DRD2HTR2ABRAFCDK2 | |
| SCHEMBL4323640 | 0.76 | CSF1R (0.66) | KDRCSF1RRETPDGFRBKIT | |
| SCHEMBL3361078 | 0.75 | CDK2 (0.54) | HRH1DRD2HTR2ABRAFTAAR1 | |
| SCHEMBL4323633 | 0.73 | CYP4F2 (0.53) | HRH1KDRCSF1RRETPDGFRB | |
| SCHEMBL4628006 | 0.73 | HRH1 (0.50) | HRH1DRD2HTR2ACDK2KMT2A | |
| SCHEMBL4314900 | 0.72 | CSNK2A2 (0.48) | CSF1RBRAFMEN1KMT2ACNR1 | |
| SCHEMBL6283187 | 0.72 | MAP4K4 (0.48) | KCNN3CDK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569917-A4 | PYRAZINE-BASED TUBULIN INHIBITORS | CYTOPIA PTY LTD (AU) | 2007-08-15 | — | — | EP | disclosed |
| EP-1569917-A1 | PYRAZINE-BASED TUBULIN INHIBITORS | Cytopia PTY Ltd (AU) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004052868-A1 | PYRAZINE-BASED TUBULIN INHIBITORS | CYTOPIA PTY LTD (AU) | 2004-06-24 | — | — | WO | disclosed |