Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.42 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5285784 | 0.95 | MAPT (0.42) | MAPTTP53POLBALDH1A1USP2 | |
| SCHEMBL5207316 | 0.93 | MAPT (0.48) | MAPTTP53POLB | |
| SCHEMBL5299157 | 0.90 | MAPT (0.44) | MAPTTP53LMNAALDH1A1GAA | |
| SCHEMBL2519786 | 0.88 | MAPT (0.44) | MAPTTP53POLBLMNAALDH1A1 | |
| SCHEMBL2519785 | 0.88 | MAPT (0.44) | MAPTTP53POLBLMNAALDH1A1 | |
| SCHEMBL5278398 | 0.86 | PPARG (0.50) | MAPTTP53ALDH1A1 | |
| SCHEMBL5213073 | 0.85 | PPARG (0.54) | — | |
| SCHEMBL2516438 | 0.83 | MAPT (0.43) | MAPTTP53POLBALDH1A1USP2 | |
| SCHEMBL2516442 | 0.83 | MAPT (0.43) | MAPTTP53POLBALDH1A1USP2 | |
| SCHEMBL5210830 | 0.82 | MAPT (0.43) | MAPTTP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448523-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | NOVARTIS AG (CH) | 2007-08-22 | — | — | EP | claimed |