Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | PDE8B | O95263 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PDE8A | O60658 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207399 | 0.93 | PPARA (0.42) | MAPTTP53POLB | |
| SCHEMBL5210969 | 0.92 | HRH3 (0.44) | HRH3 | |
| SCHEMBL5206559 | 0.91 | MAPT (0.46) | MAPTTP53 | |
| SCHEMBL2523386 | 0.89 | MAPT (0.46) | MAPTTP53HRH3PDE8BPOLB | |
| SCHEMBL2523387 | 0.89 | MAPT (0.46) | MAPTTP53HRH3PDE8BPOLB | |
| SCHEMBL5213499 | 0.88 | MAPT (0.42) | MAPTTP53 | |
| SCHEMBL5211183 | 0.88 | ALDH1A1 (0.38) | MAPTTP53POLB | |
| SCHEMBL5210317 | 0.86 | FFAR1 (0.52) | MAPTTP53 | |
| SCHEMBL5211136 | 0.85 | PPARG (0.56) | — | |
| SCHEMBL5205913 | 0.84 | FFAR1 (0.50) | MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448523-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | NOVARTIS AG (CH) | 2007-08-22 | — | — | EP | claimed |