Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.48 |
| ▸ | TP53 | P04637 | 5/20 | 0.48 |
| ▸ | PPARG | P37231 | 3/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5299157 | 0.94 | MAPT (0.44) | MAPTTP53PPARGPPARA | |
| SCHEMBL5206201 | 0.93 | MAPT (0.42) | MAPTTP53POLB | |
| SCHEMBL5285784 | 0.92 | MAPT (0.42) | MAPTTP53PPARGPPARAPOLB | |
| SCHEMBL2522432 | 0.89 | MAPT (0.49) | MAPTTP53PPARGPPARDPPARA | |
| SCHEMBL2522434 | 0.89 | MAPT (0.49) | MAPTTP53PPARGPPARDPPARA | |
| SCHEMBL2917013 | 0.88 | TP53 (0.46) | MAPTTP53PPARGPPARDPPARA | |
| SCHEMBL2521631 | 0.83 | MAPT (0.45) | MAPTTP53PPARGPPARAPOLB | |
| SCHEMBL2521633 | 0.83 | MAPT (0.45) | MAPTTP53PPARGPPARAPOLB | |
| SCHEMBL5206559 | 0.82 | MAPT (0.46) | MAPTTP53PPARGPPARDPPARA | |
| SCHEMBL5206326 | 0.81 | PPARA (0.44) | MAPTTP53PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448523-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | NOVARTIS AG (CH) | 2007-08-22 | — | — | EP | claimed |