Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5206201 | 0.95 | MAPT (0.42) | MAPTTP53ALDH1A1POLBUSP2 | |
| SCHEMBL5207316 | 0.92 | MAPT (0.48) | MAPTPPARGPPARATP53POLB | |
| SCHEMBL2516438 | 0.89 | MAPT (0.43) | MAPTPPARGPPARATP53ALDH1A1 | |
| SCHEMBL2516442 | 0.89 | MAPT (0.43) | MAPTPPARGPPARATP53ALDH1A1 | |
| SCHEMBL5299157 | 0.88 | MAPT (0.44) | MAPTPPARGPPARATP53ALDH1A1 | |
| SCHEMBL5213251 | 0.87 | TP53 (0.49) | MAPTPPARGPPARATP53POLB | |
| SCHEMBL2519786 | 0.83 | MAPT (0.44) | MAPTTP53ALDH1A1POLBUSP2 | |
| SCHEMBL2519785 | 0.83 | MAPT (0.44) | MAPTTP53ALDH1A1POLBUSP2 | |
| SCHEMBL5213073 | 0.82 | PPARG (0.54) | PPARGPPARA | |
| SCHEMBL5207399 | 0.82 | PPARA (0.42) | MAPTPPARGPPARATP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448523-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | NOVARTIS AG (CH) | 2007-08-22 | — | — | EP | claimed |