Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11809837 | 0.78 | HTT (0.34) | HTT | |
| SCHEMBL8425355 | 0.76 | NOS3 (0.36) | NOS3NOS1NOS2HTT | |
| SCHEMBL13283943 | 0.74 | NOS3 (0.35) | NOS3NOS1NOS2HTT | |
| SCHEMBL27569383 | 0.71 | TLR4 (0.36) | NOS3NOS1NOS2 | |
| SCHEMBL13284120 | 0.71 | NOS3 (0.33) | NOS3NOS1NOS2 | |
| SCHEMBL5208174 | 0.70 | — | — | |
| SCHEMBL3764553 | 0.69 | NOS3 (0.32) | NOS3NOS1NOS2 | |
| SCHEMBL3790108 | 0.69 | NOS3 (0.32) | NOS3NOS1NOS2 | |
| SCHEMBL11838587 | 0.69 | TLR4 (0.33) | NOS3NOS1NOS2 | |
| SCHEMBL11806531 | 0.68 | TLR4 (0.36) | NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343561-B1 | SERINE PROTEASE INHIBITORS | TULARIK LTD (GB) | 2007-02-28 | — | — | EP | disclosed |
| EP-1343561-A1 | SERINE PROTEASE INHIBITORS | Tularik Limited (GB) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002047762-A1 | SERINE PROTEASE INHIBITORS | TULARIK LIMITED (GB) | 2002-06-20 | — | — | WO | disclosed |