Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | PLG | P00747 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
| ▸ | TLR4 | O00206 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3764553 | 1.00 | NOS3 (0.32) | NOS3NOS1NOS2PLGPLAT | |
| SCHEMBL11838587 | 0.85 | TLR4 (0.33) | NOS3NOS1NOS2TLR4ALDH1A1 | |
| SCHEMBL27868761 | 0.80 | BRD4 (0.38) | ALDH1A1MAPTGAAHPGD | |
| SCHEMBL5739433 | 0.79 | ALDH1A1 (0.50) | LMNATLR4ALDH1A1MAPTGAA | |
| SCHEMBL8083254 | 0.74 | TLR4 (0.34) | TLR4ALDH1A1 | |
| SCHEMBL29595225 | 0.74 | TLR4 (0.34) | TLR4ALDH1A1 | |
| SCHEMBL29595955 | 0.74 | TLR4 (0.34) | TLR4ALDH1A1 | |
| SCHEMBL13283943 | 0.74 | NOS3 (0.35) | NOS3NOS1NOS2 | |
| SCHEMBL29191271 | 0.72 | TLR4 (0.48) | AKR1C4AKR1C3AKR1C2TLR4ALDH1A1 | |
| SCHEMBL8425355 | 0.71 | NOS3 (0.36) | NOS3NOS1NOS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010135524-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |