Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.40 |
| ▸ | KYNU | Q16719 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5205933 | 1.00 | HIF1A (0.46) | HIF1ALMNAKDM4EADRB1ADRA1A | |
| SCHEMBL14694764 | 0.83 | OPRK1 (0.42) | HIF1ALMNAKDM4EADRB1ADRA1A | |
| SCHEMBL15609345 | 0.83 | ALDH1A1 (0.43) | RAB9AALOX5ALDH1A1 | |
| SCHEMBL15768284 | 0.83 | OPRK1 (0.42) | HIF1ALMNAKDM4EADRB1ADRA1A | |
| SCHEMBL15229301 | 0.81 | OPRK1 (0.41) | HIF1ALMNAKDM4EADRB1ADRA1A | |
| SCHEMBL2429212 | 0.80 | ESR1 (0.42) | LMNAADRA1AOPRM1DRD1DRD3 | |
| SCHEMBL1448846 | 0.80 | ESR1 (0.42) | LMNAADRA1AOPRM1DRD1DRD3 | |
| SCHEMBL5502271 | 0.79 | TAAR1 (0.44) | HTR2AHTR2BSLC6A3 | |
| SCHEMBL3274216 | 0.74 | OPRM1 (0.57) | HIF1ALMNAKDM4EADRB1ADRA1A | |
| SCHEMBL19881826 | 0.73 | OPRM1 (0.53) | HIF1ALMNAKDM4EADRB1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7160887-B1 | Aromatic amine derivatives, their production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-09 | — | — | US | disclosed |