SCHEMBL5206532

SCHEMBL5206532

CCOC(=O)CCCN(C(=O)c1ccc(-c2ccccc2)cc1)c1ccc(Cl)cc1Oc1cccc([C@@H](C)NC(=O)OC(C)(C)C)c1

nearest known ligand 0.39

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 2/20 0.39
PTGER4 P35408 2/20 0.38
TSPO P30536 1/20 0.37
MMEL1 Q495T6 1/20 0.37
PPARG P37231 3/20 0.36
PTGER2 P43116 1/20 0.36
CTSK P43235 2/20 0.36
ALDH1A1 P00352 2/20 0.35
MAPT P10636 2/20 0.35
PFKFB3 Q16875 1/20 0.35
ROCK2 O75116 1/20 0.34
ROCK1 Q13464 1/20 0.34
KDM4E B2RXH2 1/20 0.33
GAA P10253 1/20 0.33
PKM P14618 1/20 0.33
HPGD P15428 1/20 0.33
ALOX12 P18054 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5204339 1.00 SCN9A (0.39) SCN9APTGER4TSPOMMEL1PPARG
SCHEMBL5205817 0.92 PTGER4 (0.40) SCN9APTGER4TSPOPPARGPTGER2
SCHEMBL5204784 0.92 PTGER4 (0.40) SCN9APTGER4TSPOPPARGPTGER2
SCHEMBL5208483 0.87 SCN9A (0.36) SCN9ATSPOMMEL1ALDH1A1MAPT
SCHEMBL5205929 0.86 PPARG (0.40) SCN9ATSPOMMEL1PPARGMAPT
SCHEMBL5208601 0.84 PPARG (0.39) SCN9ATSPOMMEL1PPARGMAPT
SCHEMBL5201675 0.82 PPARG (0.40) SCN9ATSPOPPARGROCK2ROCK1
SCHEMBL5206331 0.79 TSPO (0.37) SCN9APTGER4TSPO
SCHEMBL5208051 0.78 MEN1 (0.41) PTGER4PTGER2CTSKALDH1A1MAPT
SCHEMBL5202385 0.78 MEN1 (0.41) PTGER4PTGER2CTSKALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7160887-B1 Aromatic amine derivatives, their production and use TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-01-09 US disclosed
EP-1123918-B1 AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME TAKEDA PHARMACEUTICAL (JP) 2005-03-09 EP disclosed
EP-1123918-A1 AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME Takeda Chemical Industries, Ltd. (JP) 2001-08-16 EP disclosed