Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | SELE | P16581 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | CASP7 | P55210 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5205294 | 0.87 | MMP13 (0.40) | MAPTLMNAKMT2AMEN1KDM4E | |
| SCHEMBL5205013 | 0.87 | KCNH2 (0.40) | MAPTICAM1SELEKMT2AMEN1 | |
| SCHEMBL1375252 | 0.85 | MAPT (0.41) | MAPTLMNAICAM1SELEKMT2A | |
| SCHEMBL1376217 | 0.80 | NUDT1 (0.43) | MAPTLMNAKMT2AMEN1NPSR1 | |
| SCHEMBL5202871 | 0.79 | STK17A (0.42) | MAPTLMNAKMT2AMEN1NPSR1 | |
| SCHEMBL1376082 | 0.78 | STK17A (0.41) | MAPTLMNAKMT2AMEN1NPSR1 | |
| SCHEMBL1376097 | 0.78 | STK17A (0.41) | MAPTLMNAKMT2AMEN1NPSR1 | |
| SCHEMBL5204559 | 0.78 | STK17A (0.41) | MAPTLMNAKMT2AMEN1NPSR1 | |
| SCHEMBL7708449 | 0.77 | NPC1 (0.45) | MAPTKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL23472667 | 0.76 | TNF (0.49) | HTTTSHRUSP2L3MBTL1TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | claimed |
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | disclosed |
| US-6916820-B1 | Neurotrophic substituted pyrimidines | KRENITSKY PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | disclosed |