Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.43 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202458 | 0.87 | DHFR (0.48) | DHFR | |
| SCHEMBL5204379 | 0.85 | DHFR (0.37) | DHFR | |
| SCHEMBL5205280 | 0.85 | DHFR (0.45) | DHFRPIK3CA | |
| SCHEMBL5203003 | 0.85 | DHFR (0.40) | DHFR | |
| SCHEMBL5204607 | 0.85 | DHFR (0.40) | DHFR | |
| SCHEMBL5202937 | 0.84 | TRAP1 (0.42) | DHFRTRAP1PIK3CAPIK3CB | |
| SCHEMBL7157196 | 0.81 | RPS6KB1 (0.43) | RPS6KB1SMO | |
| SCHEMBL7714161 | 0.81 | DHFR (0.44) | DHFRRPS6KB1 | |
| SCHEMBL7714159 | 0.81 | DHFR (0.42) | DHFRRPS6KB1 | |
| SCHEMBL7458908 | 0.77 | RPS6KB1 (0.42) | RPS6KB1SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | claimed |
| US-6583148-B1 | Neurodegenerative or other neurological disorders; enhancing the effect of nerve growth factor; 2-Amino-5-(4-chlorophenoxy)-4-trans-4-hydroxycyclohexylamino) pyrimidine | KRENITSKY PHARMACEUTICALS, INC. | 2003-06-24 | — | — | US | claimed |
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | disclosed |
| US-6916820-B1 | Neurotrophic substituted pyrimidines | KRENITSKY PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | disclosed |
| US-6583148-B1 | Neurodegenerative or other neurological disorders; enhancing the effect of nerve growth factor; 2-Amino-5-(4-chlorophenoxy)-4-trans-4-hydroxycyclohexylamino) pyrimidine | KRENITSKY PHARMACEUTICALS, INC. | 2003-06-24 | — | — | US | disclosed |