Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9036055 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2PKMCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL8488469 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2PKMCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL5778346 | 0.81 | SMN1; SMN2 (0.52) | SMN1; SMN2PKMCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL12448183 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2PKMCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL10160044 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2PKMCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL738198 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2PKMCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL824919 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2PKMCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL5486914 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2PKMCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL8487298 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2PKMCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL828715 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2PKMCYP3A4CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1175213-A4 | HETEROCYCLIC AROMATIC COMPOUNDS USEFUL AS GROWTH HORMONE SECRETAGOGUES | BRISTOL MYERS SQUIBB CO (US) | 2007-04-11 | — | — | EP | disclosed |
| US-7053110-B2 | Heterocyclic aromatic compounds useful as growth hormone secreagogues | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-05-30 | — | — | US | disclosed |
| US-6969727-B2 | Heterocyclic aromatic compounds useful as growth hormone secretagogues | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-11-29 | — | — | US | disclosed |
| US-6908938-B2 | Heterocyclic aromatic compounds useful as growth hormone secretagogues | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-06-21 | — | — | US | disclosed |
| US-20040072881-A1 | Heterocyclic aromatic compounds useful as growth hormone secreagogues | ROBL JEFFREY A (US) | 2004-04-15 | — | — | US | disclosed |
| US-20040029935-A1 | Heterocyclic aromatic compounds useful as growth hormone secretagogues | ROBL JEFFREY A (US) | 2004-02-12 | — | — | US | disclosed |
| US-20040002525-A1 | Heterocyclic aromatic compounds useful as growth hormone secretagogues | A ROBL JEFFREY (US) | 2004-01-01 | — | — | US | disclosed |
| US-6660760-B1 | Treating obesity, osteoporosis | BRISTOL-MYERS SQUIBB CO. | 2003-12-09 | — | — | US | disclosed |
| US-6525203-B1 | Treating obesity, osteoporosis by improving bone density and stimulating increase in muscle mass and strength | BRISTOL-MYERS SQUIBB COMPANY | 2003-02-25 | — | — | US | disclosed |
| US-6518292-B1 | Stimulating endogenous production or release of growth hormone and in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength | BRISTOL-MYERS SQUIBB CO. | 2003-02-11 | — | — | US | disclosed |
| EP-1175213-A2 | HETEROCYCLIC AROMATIC COMPOUNDS USEFUL AS GROWTH HORMONE SECRETAGOGUES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000054729-A2 | HETEROCYCLIC AROMATIC COMPOUNDS USEFUL AS GROWTH HORMONE SECRETAGOGUES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072881-A1 | Heterocyclic aromatic compounds useful as growth hormone secreagogues | GHSR, GHRHR, SHBG | SMN1; SMN2 1325/4885PKM 3025/4885CYP3A4 443/4885 |
| US-20040002525-A1 | Heterocyclic aromatic compounds useful as growth hormone secretagogues | GHSR, GHRHR, NPY4R | SMN1; SMN2 1071/4885PKM 2867/4885CYP3A4 555/4885 |
| US-20040029935-A1 | Heterocyclic aromatic compounds useful as growth hormone secretagogues | GHSR, GHRHR, NPY4R | SMN1; SMN2 1071/4885PKM 2867/4885CYP3A4 555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.