Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.60 |
| ▸ | JAK1 | P23458 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | SMO | Q99835 | 7/20 | 0.57 |
| ▸ | NR2E3 | Q9Y5X4 | 4/20 | 0.56 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.52 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207022 | 0.85 | MAOA (0.55) | NPC1RAB9ANR2E3NAMPTKCNK3 | |
| SCHEMBL5208301 | 0.82 | KCNK3 (0.57) | NPC1RAB9AKCNK3KCNK9MAPT | |
| SCHEMBL15060321 | 0.82 | NAMPT (0.59) | NPC1RAB9ANAMPTMAPTKDM4E | |
| SCHEMBL4464384 | 0.81 | KIT (0.67) | JAK2JAK1NPC1RAB9ASMO | |
| SCHEMBL14182736 | 0.80 | MAOA (0.67) | JAK2NPC1RAB9ANAMPTMAPT | |
| SCHEMBL14182739 | 0.79 | MAOA (0.59) | JAK2NPC1RAB9AMAPTKDM4E | |
| SCHEMBL18145948 | 0.77 | MEN1 (0.43) | JAK2JAK1NPC1RAB9ANR2E3 | |
| SCHEMBL21022000 | 0.77 | NAMPT (0.42) | JAK2JAK1NPC1RAB9ANR2E3 | |
| SCHEMBL18145945 | 0.77 | MEN1 (0.43) | JAK2JAK1NPC1RAB9ANR2E3 | |
| SCHEMBL28671945 | 0.76 | GUSB (0.53) | NPC1RAB9ANAMPTMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833829-A2 | BENZAMIDE SUBSTITUTED IMIDAZO- AND PYRROLO-PYRIDINES AS PROTEIN KINASE INHIBITORS | F. Hoffmann-Roche AG (CH) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006066913-A2 | BENZAMIDE SUBSTITUTED IMIDAZO- AND PYROLO-PYRIDINES AS PROTEIN KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-29 | — | — | WO | disclosed |