Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 5/20 | 0.57 |
| ▸ | KCNK9 | Q9NPC2 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 2/20 | 0.52 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207022 | 0.85 | MAOA (0.55) | KCNK3KCNK9KMT2AMEN1RAB9A | |
| SCHEMBL4487398 | 0.83 | KIT (0.65) | KCNK3KCNK9ADORA3ADORA2AADORA1 | |
| SCHEMBL5207314 | 0.82 | JAK2 (0.60) | KCNK3KCNK9KMT2AMEN1RAB9A | |
| SCHEMBL15060321 | 0.79 | NAMPT (0.59) | KMT2APOLBMEN1RAB9AMAPT | |
| SCHEMBL14182769 | 0.78 | KCNQ2 (0.64) | KCNK9KMT2AMEN1RAB9AMAPT | |
| SCHEMBL5210856 | 0.78 | KCNQ2 (0.55) | KMT2AMEN1RAB9AMAPTALDH1A1 | |
| SCHEMBL14182736 | 0.77 | MAOA (0.67) | KMT2ARAB9AMAPTALDH1A1NPC1 | |
| SCHEMBL15764666 | 0.77 | NPC1 (0.81) | KCNK3KCNK9KMT2APOLBMEN1 | |
| SCHEMBL4469526 | 0.75 | MAPK1 (0.62) | KCNK3KCNK9KMT2APOLBMEN1 | |
| SCHEMBL2362772 | 0.74 | KMT2A (0.82) | KCNK3KCNK9KMT2APOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833829-A2 | BENZAMIDE SUBSTITUTED IMIDAZO- AND PYRROLO-PYRIDINES AS PROTEIN KINASE INHIBITORS | F. Hoffmann-Roche AG (CH) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006066913-A2 | BENZAMIDE SUBSTITUTED IMIDAZO- AND PYROLO-PYRIDINES AS PROTEIN KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-29 | — | — | WO | disclosed |