Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | APLNR | P35414 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | FPR1 | P21462 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207259 | 0.78 | POLB (0.47) | MEN1KMT2AHPGDUSP2APLNR | |
| SCHEMBL5203831 | 0.76 | TSHR (0.46) | MEN1KMT2AAPLNRTDP1LMNA | |
| SCHEMBL5205361 | 0.73 | MAPT (0.54) | MEN1KMT2AAPLNRTDP1LMNA | |
| SCHEMBL11223428 | 0.68 | SMN1; SMN2 (0.38) | MEN1KMT2ATDP1POLBALDH1A1 | |
| SCHEMBL13125312 | 0.68 | LMNA (0.73) | MEN1KMT2AHPGDUSP2MAPK1 | |
| SCHEMBL5207452 | 0.67 | MEN1 (0.39) | MEN1KMT2AGFER | |
| SCHEMBL13167712 | 0.67 | APLNR (0.68) | MEN1KMT2AUSP2APLNRTDP1 | |
| SCHEMBL5207054 | 0.67 | GAA (0.49) | MEN1KMT2AHPGDUSP2APLNR | |
| SCHEMBL13125320 | 0.66 | LMNA (0.56) | MEN1KMT2AGFERTAAR1HPGD | |
| SCHEMBL2608965 | 0.65 | KDM4E (0.43) | MEN1KMT2AGFERTDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802590-A1 | SUBSTITUTED N-ALKYLPYRIMIDINONES | Pharmacia & Upjohn Company LLC (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040666-A1 | SUBSTITUTED N-ALKYLPYRIMIDINONES | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-04-20 | — | — | WO | disclosed |