Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | APLNR | P35414 | 9/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | FPR1 | P21462 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5209342 | 0.77 | L3MBTL1 (0.41) | TSHRAPLNRTDP1LMNAPKM | |
| SCHEMBL5205361 | 0.77 | MAPT (0.54) | TSHRAPLNRTDP1LMNAPKM | |
| SCHEMBL5207656 | 0.76 | MEN1 (0.53) | TSHRAPLNRTDP1LMNAPKM | |
| SCHEMBL17382812 | 0.72 | MEN1 (0.53) | TSHRAPLNRTDP1LMNAMAPT | |
| SCHEMBL13167712 | 0.70 | APLNR (0.68) | TSHRAPLNRTDP1MAPTKMT2A | |
| SCHEMBL5207054 | 0.70 | GAA (0.49) | TSHRAPLNRTDP1LMNAPKM | |
| SCHEMBL5207259 | 0.69 | POLB (0.47) | TSHRAPLNRTDP1LMNAPKM | |
| SCHEMBL17979301 | 0.68 | TSHR (0.58) | TSHRAPLNRLMNAMAPTKMT2A | |
| SCHEMBL30879077 | 0.64 | PIM1 (0.39) | KMT2AMEN1 | |
| SCHEMBL13678619 | 0.62 | TSHR (0.54) | TSHRAPLNRLMNAKMT2ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802590-A1 | SUBSTITUTED N-ALKYLPYRIMIDINONES | Pharmacia & Upjohn Company LLC (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040666-A1 | SUBSTITUTED N-ALKYLPYRIMIDINONES | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-04-20 | — | — | WO | disclosed |