Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8840880 | 0.81 | PDE4A (0.67) | PDGFRBPDGFRAPDE4AALDH1A1KDM4E | |
| SCHEMBL5535149 | 0.80 | PDGFRB (0.47) | PDGFRBPDGFRAPDE4AALDH1A1KDM4E | |
| SCHEMBL6029081 | 0.76 | PDGFRB (0.58) | PDGFRBPDGFRAPDE4AKDM4EGAK | |
| SCHEMBL3769943 | 0.76 | PDGFRB (0.58) | PDGFRBPDGFRAPDE4AALDH1A1KDM4E | |
| SCHEMBL1897455 | 0.74 | ESR2 (0.50) | PDGFRBPDGFRAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5832416 | 0.73 | PDGFRB (0.55) | PDGFRBPDGFRAPDE4AALDH1A1KDM4E | |
| SCHEMBL7616076 | 0.73 | ALDH1A1 (0.58) | PDGFRBPDGFRAPDE4AALDH1A1KDM4E | |
| SCHEMBL16541896 | 0.73 | PDE4A (0.57) | PDGFRBPDGFRAPDE4AALDH1A1KDM4E | |
| SCHEMBL28467263 | 0.72 | PDE4A (0.52) | PDGFRBPDGFRAPDE4AALDH1A1KDM4E | |
| SCHEMBL11330797 | 0.72 | MAPT (0.61) | PDGFRBPDGFRAPDE4AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453514-B1 | PIPERAZINE DERIVATIVES FOR USE AS CCR-3 RECEPTOR ANTAGONISTS IN THE TREATMENT OF ASTHMA | HOFFMANN LA ROCHE (CH) | 2007-07-18 | — | — | EP | claimed |
| US-7049317-B2 | CCR-3 receptor antagonists | SYNTEX (U.S.A.) LLC (US) | 2006-05-23 | — | — | US | claimed |
| US-6977265-B2 | Piperidine CCR-3 receptor antagonists | ROCHE PALO ALTO LLC (US) | 2005-12-20 | — | — | US | claimed |
| US-6906073-B2 | Piperazine CCR-3 receptor antagonists | ROCHE PALO ALTO LLC (US) | 2005-06-14 | — | — | US | claimed |
| EP-1453514-A1 | PIPERAZINE DERIVATIVES FOR USE AS CCR-3 RECEPTOR ANTAGONISTS IN THE TREATMENT OF ASTHMA | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-08 | — | — | EP | claimed |
| EP-1453825-A1 | N-UREIDO-PIPERIDINES AS ANTAGONISTS VIII FOR CCR-3 RECEPTOR | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-08 | — | — | EP | claimed |
| EP-1427696-A1 | CCR-3 RECEPTOR ANTAGONISTS V | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-16 | — | — | EP | claimed |
| US-20030229121-A1 | Piperidine CCR-3 receptor antagonists | SYNTEX (U.S.A.) LLC | 2003-12-11 | — | — | US | claimed |
| US-20030176441-A1 | Piperazine CCR-3 receptor antagonists | ROCHE PALO ALTO LLC | 2003-09-18 | — | — | US | claimed |
| US-20030119885-A1 | CCR-3 receptor antagonists | SYNTEX (U.S.A.) LLC | 2003-06-26 | — | — | US | claimed |
| WO-2003045393-A1 | PIPERAZINE DERIVATIVES FOR USE AS CCR-3 RECEPTOR ANTAGONISTS IN THE TREATMENT OF ASTHMA | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-05 | — | — | WO | claimed |
| WO-2003045937-A1 | N-UREIDO-PIPERIDINES AS ANTAGONISTS VIII FOR CCR-3 RECEPTOR | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-05 | — | — | WO | claimed |
| WO-2003022799-A1 | CCR-3 RECEPTOR ANTAGONISTS V | F. HOFFMANN-LA ROCHE AG (CH) | 2003-03-20 | — | — | WO | claimed |
| US-6166015-A | Pyrrolidine derivatives-CCR-3 receptor antagonists | SYNTEX (U.S.A.) INC. (US) | 2000-12-26 | — | — | US | claimed |
| EP-1358181-B1 | SUBSTITUTED PYRROLIDINES AS CCR-3 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-09-26 | — | — | EP | disclosed |
| EP-1453514-B1 | PIPERAZINE DERIVATIVES FOR USE AS CCR-3 RECEPTOR ANTAGONISTS IN THE TREATMENT OF ASTHMA | HOFFMANN LA ROCHE (CH) | 2007-07-18 | — | — | EP | disclosed |
| US-20060194790-A1 | Bridged bicyclic amine derivatives useful as CCR-3 receptor antagonists | GONG LEYI | 2006-08-31 | — | — | US | disclosed |
| EP-1131288-A1 | PYRROLIDINE DERIVATIVES-CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-09-12 | — | — | EP | disclosed |
| US-6166015-A | Pyrrolidine derivatives-CCR-3 receptor antagonists | SYNTEX (U.S.A.) INC. (US) | 2000-12-26 | — | — | US | disclosed |
| WO-2000031032-A1 | PYRROLIDINE DERIVATIVES-CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229121-A1 | Piperidine CCR-3 receptor antagonists | CCR1, CCR3, CCRL2 | PDGFRB 331/4885PDGFRA 232/4885PDE4A 1434/4885 |
| US-20030119885-A1 | CCR-3 receptor antagonists | CCR1, CCR3, CCR4 | PDGFRB 650/4885PDGFRA 682/4885PDE4A 1053/4885 |
| US-20030176441-A1 | Piperazine CCR-3 receptor antagonists | CCR3, CCR1, CCRL2 | PDGFRB 399/4885PDGFRA 279/4885PDE4A 914/4885 |
| US-20060194790-A1 | Bridged bicyclic amine derivatives useful as CCR-3 receptor antagonists | CCR3, CCR10, CCR1 | PDGFRB 1156/4885PDGFRA 1202/4885PDE4A 3530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.