Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | NPC1 | O15118 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 8/20 | 0.34 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 3/20 | 0.34 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6999298 | 0.96 | HRH2 (0.37) | HRH2HRH1HRH4HRH3ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL5205822 | 0.94 | F2 (0.34) | HRH2HRH1HRH4HRH3LMNA | |
| Trifluoroacetic Acid SCHEMBL6993355 | 0.90 | OPRM1 (0.33) | HRH2HRH1HRH4HRH3LMNA | |
| Trifluoroacetic Acid SCHEMBL5206361 | 0.87 | HRH2 (0.34) | HRH2HRH1HRH4HRH3ALDH1A1 | |
| SCHEMBL5210132 | 0.83 | F2 (0.39) | ALDH1A1NPC1RAB9ATP53MAPT | |
| Trifluoroacetic Acid SCHEMBL6996192 | 0.83 | HRH2 (0.34) | HRH2HRH1HRH4HRH3ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL5209729 | 0.83 | F2 (0.34) | F2TPSAB1 | |
| Trifluoroacetic Acid SCHEMBL5206983 | 0.80 | MAPT (0.41) | ALDH1A1NPC1RAB9ATP53NPSR1 | |
| Trifluoroacetic Acid SCHEMBL5211180 | 0.80 | NPC1 (0.39) | ALDH1A1NPC1RAB9ATP53MAPT | |
| Trifluoroacetic Acid SCHEMBL5208806 | 0.79 | MAPT (0.37) | ALDH1A1NPC1RAB9ATP53NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343561-B1 | SERINE PROTEASE INHIBITORS | TULARIK LTD (GB) | 2007-02-28 | — | — | EP | disclosed |
| EP-1343561-A1 | SERINE PROTEASE INHIBITORS | Tularik Limited (GB) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002047762-A1 | SERINE PROTEASE INHIBITORS | TULARIK LIMITED (GB) | 2002-06-20 | — | — | WO | disclosed |