Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 17/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5210560 | 0.91 | HRH3 (0.59) | HRH3 | |
| SCHEMBL5213574 | 0.90 | HRH3 (0.58) | HRH3 | |
| SCHEMBL5210399 | 0.85 | HRH3 (0.62) | HRH3SMN1; SMN2 | |
| SCHEMBL5210405 | 0.84 | HRH3 (0.61) | HRH3 | |
| SCHEMBL5210985 | 0.84 | HRH3 (0.56) | HRH3SMN1; SMN2AKR1C3 | |
| SCHEMBL5212607 | 0.81 | HRH3 (0.59) | HRH3ACACB | |
| SCHEMBL5210165 | 0.81 | HRH3 (0.59) | HRH3 | |
| SCHEMBL5210077 | 0.81 | HRH3 (0.58) | HRH3 | |
| SCHEMBL5213801 | 0.80 | HRH3 (0.56) | HRH3ACACB | |
| SCHEMBL5209401 | 0.80 | ALDH1A1 (0.64) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646620-B1 | SUBSTITUTED PIPERIDINES AS HISTAMINE H3 RECEPTOR LIGANDS | GLAXO GROUP LTD (GB) | 2007-08-15 | — | — | EP | claimed |