SCHEMBL5209110

SCHEMBL5209110

Cc1cc(Cc2ccc(Cl)c(Oc3cc(Br)c[nH]c3=O)c2F)n[nH]c1=O

nearest known ligand 0.59

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.59
CYP2C9 P11712 1/20 0.59
CYP2C19 P33261 1/20 0.59
SLC5A2 P31639 1/20 0.38
DAO P14920 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5377687 0.81 CYP3A4 (0.64) CYP3A4CYP2C9CYP2C19SLC5A2
SCHEMBL5368877 0.80 CYP3A4 (0.70) CYP3A4CYP2C9CYP2C19SLC5A2DAO
SCHEMBL5370974 0.80 CYP3A4 (0.73) CYP3A4CYP2C9CYP2C19SLC5A2DAO
SCHEMBL4278760 0.80 CYP3A4 (0.62) CYP3A4CYP2C9CYP2C19SLC5A2
SCHEMBL5374165 0.79 CYP3A4 (0.74) CYP3A4CYP2C9CYP2C19SLC5A2
SCHEMBL5368683 0.79 CYP3A4 (0.56) CYP3A4CYP2C9CYP2C19SLC5A2DAO
SCHEMBL4268874 0.79 CYP3A4 (0.56) CYP3A4CYP2C9CYP2C19SLC5A2DAO
SCHEMBL5373905 0.77 CYP3A4 (0.56) CYP3A4CYP2C9CYP2C19SLC5A2DAO
SCHEMBL5376896 0.76 CYP3A4 (0.65) CYP3A4CYP2C9CYP2C19SLC5A2
SCHEMBL5364607 0.76 CYP3A4 (0.56) CYP3A4CYP2C9CYP2C19SLC5A2DAO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1737827-A1 PROCESS FOR PREPARING PYRIDAZINONE COMPOUNDS F.HOFFMANN-LA ROCHE AG (CH) 2007-01-03 EP disclosed
EP-1608629-A1 BENZYL-PYRIDAZINONS AS REVERSE TRANSCRIPTASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2005-12-28 EP disclosed
WO-2005100323-A1 PROCESS FOR PREPARING PYRIDAZINONE COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2005-10-27 WO disclosed
WO-2004085406-A1 BENZYL-PYRIDAZINONS AS REVERSE TRANSCRIPTASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2004-10-07 WO disclosed