SCHEMBL5209735

SCHEMBL5209735

O=C(O)N1CCC(COc2ccc(-c3ccc(C(F)(F)F)cc3)cc2)CC1

nearest known ligand 0.58

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 1/20 0.44
PPARA Q07869 1/20 0.44
LIPE Q05469 3/20 0.44
FFAR4 Q5NUL3 3/20 0.44
CHRM4 P08173 1/20 0.43
KIF11 P52732 1/20 0.43
HRH3 Q9Y5N1 1/20 0.42
CHRNA7 P36544 1/20 0.42
KCNH2 Q12809 1/20 0.42
ENPP2 Q13822 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL388832 0.84 GPR119 (0.54)
SCHEMBL14431524 0.83 LIPE (0.44) PPARDPPARALIPEKIF11
SCHEMBL13519209 0.81 MEN1 (0.56)
SCHEMBL29716381 0.81 GPR119 (0.55)
SCHEMBL2463086 0.81 FAAH (0.52) LIPECHRNA7
SCHEMBL12813444 0.80 GRIN2D (0.53)
SCHEMBL13281379 0.80 HRH3 (0.56) LIPEHRH3
SCHEMBL796332 0.80 GRIN2D (0.55)
SCHEMBL5207764 0.79 POLB (0.56)
SCHEMBL214491 0.79 PARP15 (0.51)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1708994-B1 ARYLOXYALKYLCARBAMATE-TYPE DERIVATIVES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS SANOFI AVENTIS (FR) 2007-08-08 EP claimed
EP-1708994-B1 ARYLOXYALKYLCARBAMATE-TYPE DERIVATIVES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS SANOFI AVENTIS (FR) 2007-08-08 EP disclosed