Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.41 |
| ▸ | CCR3 | P51677 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1815889 | 0.85 | DRD2 (0.49) | SIGMAR1DRD2DRD3 | |
| SCHEMBL5213714 | 0.78 | HRH1 (0.52) | HRH1CCR3KCNH2SIGMAR1DRD2 | |
| SCHEMBL998038 | 0.72 | RORC (0.39) | SIGMAR1 | |
| SCHEMBL17593793 | 0.71 | L3MBTL3 (0.34) | HRH1CCR3KCNH2 | |
| SCHEMBL5209182 | 0.68 | CHRM5 (0.38) | SIGMAR1 | |
| SCHEMBL11084741 | 0.68 | DRD2 (0.67) | KCNH2SIGMAR1DRD2DRD3 | |
| SCHEMBL5795262 | 0.68 | — | — | |
| SCHEMBL17838713 | 0.67 | L3MBTL3 (0.42) | — | |
| SCHEMBL5544898 | 0.67 | FFAR4 (0.53) | HRH1DRD2DRD3 | |
| SCHEMBL27097468 | 0.66 | CHRM5 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646620-B1 | SUBSTITUTED PIPERIDINES AS HISTAMINE H3 RECEPTOR LIGANDS | GLAXO GROUP LTD (GB) | 2007-08-15 | — | — | EP | disclosed |
| EP-1646620-A1 | SUBSTITUTED PIPERIDINES AS HISTAMINE H3 RECEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2006-04-19 | — | — | EP | disclosed |
| WO-2005014571-A1 | SUBSTITUTED PIPERIDINES AS HISTAMINE H3 RECEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2005-02-17 | — | — | WO | disclosed |