Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.52 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL379054 | 0.85 | ALDH1A1 (0.67) | POLBTHRBMAPTHTTALDH1A1 | |
| SCHEMBL30643052 | 0.85 | POLB (0.62) | POLBTHRBMAPTHTTALDH1A1 | |
| SCHEMBL8265824 | 0.85 | POLB (0.62) | POLBTHRBMAPTHTTALDH1A1 | |
| SCHEMBL2625191 | 0.83 | POLB (0.59) | POLBTHRBMAPTHTTALDH1A1 | |
| SCHEMBL13015507 | 0.83 | POLB (0.63) | POLBTHRBMAPTHTTALDH1A1 | |
| SCHEMBL18165460 | 0.81 | POLB (0.61) | POLBTHRBMAPTMAOBMEN1 | |
| SCHEMBL5206777 | 0.81 | GABRP (0.54) | ALDH1A1CSNK2A2CSNK2BCSNK2A1MAOB | |
| SCHEMBL22617461 | 0.79 | MAOB (0.76) | POLBTHRBMAPTCSNK2A2CSNK2B | |
| SCHEMBL4504897 | 0.78 | TAS1R3 (0.54) | MAPTALDH1A1MAOBKDM4EHPGD | |
| SCHEMBL6633181 | 0.78 | CSNK2A2 (0.72) | POLBMAPTHTTALDH1A1CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711490-A4 | NOVEL P-GLYCOPROTEIN INHIBITOR, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | HANMI PHARM IND CO LTD (KR) | 2007-04-04 | — | — | EP | disclosed |
| EP-1711490-A1 | NOVEL P-GLYCOPROTEIN INHIBITOR, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Hanmi Pharm. Co., Ltd. (KR) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005033101-A1 | NOVEL P-GLYCOPROTEIN INHIBITOR, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | HANMI PHARM. CO., LTD. (KR) | 2005-04-14 | — | — | WO | disclosed |