Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 15/20 | 0.32 |
| ▸ | BRAF | P15056 | 15/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 2/20 | 0.31 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.31 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.31 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2984010 | 0.78 | EIF2AK2 (0.39) | RAF1BRAFCDK2CLK1PIK3CA | |
| SCHEMBL5147388 | 0.77 | ALDH1A1 (0.41) | RAF1BRAFCDK2CLK1EIF2AK2 | |
| SCHEMBL3167891 | 0.71 | EIF2AK2 (0.35) | RAF1BRAFCDK2CLK1EIF2AK2 | |
| SCHEMBL2986650 | 0.69 | CDK2 (0.37) | RAF1BRAFCDK2CLK1EIF2AK2 | |
| SCHEMBL5148871 | 0.68 | ALDH1A1 (0.40) | CDK2CLK1NPC1RAB9A | |
| SCHEMBL2978487 | 0.68 | EIF2AK2 (0.37) | RAF1BRAFCDK2CLK1EIF2AK2 | |
| SCHEMBL5147284 | 0.67 | ALDH1A1 (0.36) | RAF1BRAFCDK2CLK1EIF2AK2 | |
| SCHEMBL2982460 | 0.63 | EIF2AK2 (0.38) | RAF1BRAFCDK2CLK1EIF2AK2 | |
| SCHEMBL3071448 | 0.62 | CDK2 (0.35) | RAF1BRAFCDK2CLK1EIF2AK2 | |
| SCHEMBL2971966 | 0.62 | EIF2AK2 (0.38) | RAF1BRAFEIF2AK2FLT3ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |