Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.77 |
| ▸ | PSMB1 | P20618 | 9/20 | 0.75 |
| ▸ | PSMB5 | P28074 | 9/20 | 0.75 |
| ▸ | PSMB2 | P49721 | 7/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | LTA4H | P09960 | 1/20 | 0.69 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | ESR1 | P03372 | 1/20 | 0.62 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12193816 | 0.98 | KDM4E (0.80) | KDM4EPSMB1PSMB5PSMB2ALDH1A1 | |
| SCHEMBL7738349 | 0.94 | KDM4E (0.74) | KDM4EPSMB1PSMB5PSMB2ALDH1A1 | |
| SCHEMBL5213285 | 0.92 | KDM4E (0.89) | KDM4EPSMB1PSMB5PSMB2ALDH1A1 | |
| SCHEMBL6981478 | 0.92 | KDM4E (0.89) | KDM4EPSMB1PSMB5PSMB2ALDH1A1 | |
| SCHEMBL491803 | 0.91 | KDM4E (0.92) | KDM4EPSMB1PSMB5PSMB2ALDH1A1 | |
| SCHEMBL490099 | 0.90 | KDM4E (0.80) | KDM4EALDH1A1HRH3L3MBTL1 | |
| SCHEMBL5855860 | 0.90 | KDM4E (0.90) | KDM4EPSMB1PSMB5PSMB2ALDH1A1 | |
| SCHEMBL14054622 | 0.89 | KDM4E (0.69) | KDM4EPSMB1PSMB5PSMB2ALDH1A1 | |
| SCHEMBL5856201 | 0.88 | KDM4E (0.78) | KDM4EALDH1A1HRH3L3MBTL1 | |
| SCHEMBL6597214 | 0.87 | PSMB1 (0.97) | KDM4EPSMB1PSMB5PSMB2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1011666-A4 | ANTITHROMBOTIC AGENTS | LILLY CO ELI (US) | 2004-03-31 | — | — | EP | disclosed |
| US-6172100-B1 | ADMINISTERING AMINATED 1-BENZYL-2-PHENYLINDOLE DERIVATIVES; BENZYLATION | ELI LILLY AND COMPANY | 2001-01-09 | — | — | US | disclosed |
| EP-1011666-A1 | ANTITHROMBOTIC AGENTS | ELI LILLY AND COMPANY (US) | 2000-06-28 | — | — | EP | disclosed |
| WO-1998048797-A1 | ANTITHROMBOTIC AGENTS | ELI LILLY AND COMPANY (US) | 1998-11-05 | — | — | WO | disclosed |