Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 7/20 | 0.70 |
| ▸ | TUBB | P07437 | 7/20 | 0.70 |
| ▸ | TUBA3C | P0DPH7 | 7/20 | 0.70 |
| ▸ | TUBA1B | P68363 | 7/20 | 0.70 |
| ▸ | TUBA4A | P68366 | 7/20 | 0.70 |
| ▸ | TUBB4B | P68371 | 7/20 | 0.70 |
| ▸ | TUBB3 | Q13509 | 7/20 | 0.70 |
| ▸ | TUBB2A | Q13885 | 7/20 | 0.70 |
| ▸ | TUBB8 | Q3ZCM7 | 7/20 | 0.70 |
| ▸ | TUBA3E | Q6PEY2 | 7/20 | 0.70 |
| ▸ | TUBA1A | Q71U36 | 7/20 | 0.70 |
| ▸ | TUBA1C | Q9BQE3 | 7/20 | 0.70 |
| ▸ | TUBB6 | Q9BUF5 | 7/20 | 0.70 |
| ▸ | TUBB2B | Q9BVA1 | 7/20 | 0.70 |
| ▸ | TUBB1 | Q9H4B7 | 7/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5214163 | 0.85 | TUBB4A (0.69) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7672368 | 0.83 | TUBB4A (0.74) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5808232 | 0.82 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7463688 | 0.80 | TUBB4A (0.46) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7671532 | 0.78 | HTR6 (0.68) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7381366 | 0.77 | HTR6 (0.74) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL2880010 | 0.77 | KDM4E (0.66) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL2354376 | 0.76 | TUBB4A (0.59) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7672077 | 0.76 | TUBB4A (0.67) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL22802275 | 0.76 | TUBB4A (0.82) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173421-B1 | INDOLE DERIVATIVES AS ANTI-INFLAMMATION AGENTS | ASTRAZENECA AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| US-6833387-B1 | 3-substituted indoles; inhibition of monocyte chemoattractant protein-1 and/or RANTES induced chemotaxis; inflammatory diseases | ASTRAZENECA AB (SE) | 2004-12-21 | — | — | US | disclosed |
| EP-1173421-A2 | INDOLE DERIVATIVES AS ANTI-INFLAMMATION AGENTS | AstraZeneca AB (SE) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000046199-A2 | INDOLE DERIVATIVES AS ANTI-INFLAMMATION AGENTS | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |