Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.52 |
| ▸ | PPARA | Q07869 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2807182 | 0.96 | PPARG (0.55) | PPARGPPARALMNAL3MBTL1ALDH1A1 | |
| SCHEMBL14176244 | 0.94 | LMNA (0.54) | PPARGPPARALMNAL3MBTL1ALDH1A1 | |
| SCHEMBL5207761 | 0.92 | PPARA (0.52) | PPARGPPARALMNAL3MBTL1ALDH1A1 | |
| SCHEMBL5118505 | 0.92 | OPRK1 (0.51) | PPARGPPARACYP1A2ALDH1A1OPRK1 | |
| SCHEMBL5116975 | 0.92 | OPRK1 (0.51) | PPARGPPARACYP1A2ALDH1A1OPRK1 | |
| SCHEMBL14176249 | 0.92 | PPARA (0.56) | PPARGPPARALMNACYP1A2PTGS1 | |
| SCHEMBL2804981 | 0.92 | OPRK1 (0.51) | PPARGPPARACYP1A2ALDH1A1OPRK1 | |
| SCHEMBL5113057 | 0.91 | RAB9A (0.52) | PPARGPPARALMNAL3MBTL1ALDH1A1 | |
| SCHEMBL5208740 | 0.90 | PPARA (0.62) | PPARGPPARALMNACYP1A2L3MBTL1 | |
| SCHEMBL5209756 | 0.90 | MRGPRX4 (0.53) | PPARGPPARALMNAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313717-B1 | OXAZOLYL-ARYLPROPIONIC ACID DERIVATIVES AND THEIR USE AS PPAR AGONISTS | LILLY CO ELI (US) | 2007-10-17 | — | — | EP | disclosed |