Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 4/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 3/20 | 0.36 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.36 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 4/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5213618 | 0.87 | HTR4 (0.46) | HTR4MAOBALOX15 | |
| SCHEMBL5218999 | 0.85 | HTR4 (0.49) | HTR4MAOB | |
| SCHEMBL5212995 | 0.82 | HTR4 (0.45) | HTR4SIGMAR1KDM4EALDH1A1HTR7 | |
| SCHEMBL14375265 | 0.79 | HTR4 (0.45) | HTR4ALDH1A1CARM1PRMT6PRMT1 | |
| SCHEMBL5215065 | 0.76 | HTR4 (0.49) | HTR4KDM4EALDH1A1HTR7ALOX15 | |
| SCHEMBL5219353 | 0.76 | HTR4 (0.46) | HTR4SIGMAR1KDM4EALDH1A1HTR7 | |
| SCHEMBL4347061 | 0.73 | MAOB (0.40) | HTR4MAOB | |
| SCHEMBL17285915 | 0.73 | CARM1 (0.46) | SIGMAR1KDM4EHTR7CARM1PRMT6 | |
| SCHEMBL24517948 | 0.72 | POLB (0.45) | SIGMAR1HTR7CARM1PRMT6PRMT1 | |
| SCHEMBL10218755 | 0.71 | L3MBTL1 (0.46) | KDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1112270-B1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | disclosed |