Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5212984 | 0.87 | HTR4 (0.45) | HTR4KDM4EALDH1A1ALOX15SIGMAR1 | |
| SCHEMBL5216687 | 0.84 | HTR4 (0.48) | HTR4KDM4EALOX15SIGMAR1DRD2 | |
| SCHEMBL5215065 | 0.84 | HTR4 (0.49) | HTR4KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL5213629 | 0.82 | HTR4 (0.47) | HTR4KDM4EALDH1A1ALOX15POLB | |
| SCHEMBL5216679 | 0.82 | SMN1; SMN2 (0.49) | HTR4KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL14375265 | 0.82 | HTR4 (0.45) | HTR4ALDH1A1RAB9ACARM1PRMT6 | |
| SCHEMBL13411085 | 0.79 | ALDH1A1 (0.50) | KDM4EALDH1A1NPC1RAB9AALOX15 | |
| SCHEMBL5219353 | 0.78 | HTR4 (0.46) | HTR4KDM4EALDH1A1RAB9AALOX15 | |
| SCHEMBL5215771 | 0.77 | HTR4 (0.47) | HTR4KDM4EALDH1A1ALOX15CYP1A2 | |
| SCHEMBL10263618 | 0.76 | MEN1 (0.47) | KDM4EPOLBSIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1112270-B1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | claimed |