Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.67 |
| ▸ | MGLL | Q99685 | 5/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207580 | 0.85 | HSD11B1 (0.65) | HSD11B1MGLLLMNAALDH1A1MAPT | |
| SCHEMBL1476579 | 0.81 | SLC18A3 (0.53) | HSD11B1MGLLSLC18A3LMNAALDH1A1 | |
| SCHEMBL4244603 | 0.81 | HSD11B1 (0.64) | HSD11B1MGLLSLC18A3KMT2A | |
| SCHEMBL6214094 | 0.81 | HSD11B1 (1.00) | HSD11B1MGLLLMNAALDH1A1 | |
| SCHEMBL6209178 | 0.80 | HSD11B1 (0.61) | HSD11B1MGLLHTR2AALDH1A1KMT2A | |
| SCHEMBL9485674 | 0.80 | HSD11B1 (0.62) | HSD11B1MGLLHTR2ASLC18A3ALDH1A1 | |
| SCHEMBL1429493 | 0.79 | HSD11B1 (0.64) | HSD11B1MGLLHTR2ASLC18A3LMNA | |
| SCHEMBL4772773 | 0.78 | HTT (0.61) | MGLLLMNAALDH1A1MAPTHTT | |
| SCHEMBL5211869 | 0.77 | MGLL (0.57) | HSD11B1MGLLALDH1A1MAPTHPGD | |
| SCHEMBL23865340 | 0.77 | HSD11B1 (0.59) | HSD11B1MGLLHTR2ASLC18A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153013-B1 | 5-HT1F AGONISTS | LILLY CO ELI (US) | 2007-10-31 | — | — | EP | disclosed |
| US-6777428-B1 | INHIBIT PEPTIDE EXTRAVASATION DUE TO STIMULATION OF THE TRIGEMINAL GANGLIA, AND ARE THEREFORE USEFUL FOR THE TREATMENT OF MIGRAINE AND ASSOCIATED DISORDERS | ELI LILLY AND COMPANY | 2004-08-17 | — | — | US | disclosed |
| EP-1153013-A2 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2001-11-14 | — | — | EP | disclosed |
| WO-2000047559-A2 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2000-08-17 | — | — | WO | disclosed |