Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.65 |
| ▸ | MGLL | Q99685 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5214742 | 0.85 | HSD11B1 (0.67) | HSD11B1MGLLALDH1A1MAPTKMT2A | |
| SCHEMBL6175481 | 0.82 | CES2 (0.64) | HSD11B1MGLLALDH1A1MAPTRXFP1 | |
| SCHEMBL29433469 | 0.82 | CES2 (0.64) | HSD11B1MGLLALDH1A1MAPTRXFP1 | |
| SCHEMBL6209378 | 0.81 | MGLL (0.83) | HSD11B1MGLLRXFP1KDM4EMEN1 | |
| SCHEMBL22658456 | 0.79 | ALDH1A1 (0.61) | HSD11B1MGLLALDH1A1RXFP1MEN1 | |
| SCHEMBL29433310 | 0.79 | ALDH1A1 (0.61) | HSD11B1MGLLALDH1A1RXFP1MEN1 | |
| SCHEMBL29408246 | 0.79 | CES2 (0.60) | HSD11B1MGLLALDH1A1MAPTRXFP1 | |
| SCHEMBL22658096 | 0.79 | CES2 (0.60) | HSD11B1MGLLALDH1A1MAPTRXFP1 | |
| SCHEMBL6209178 | 0.79 | HSD11B1 (0.61) | HSD11B1MGLLALDH1A1MEN1KMT2A | |
| SCHEMBL5211658 | 0.78 | HSD11B1 (0.53) | HSD11B1MGLLALDH1A1MAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153013-B1 | 5-HT1F AGONISTS | LILLY CO ELI (US) | 2007-10-31 | — | — | EP | disclosed |
| US-6777428-B1 | INHIBIT PEPTIDE EXTRAVASATION DUE TO STIMULATION OF THE TRIGEMINAL GANGLIA, AND ARE THEREFORE USEFUL FOR THE TREATMENT OF MIGRAINE AND ASSOCIATED DISORDERS | ELI LILLY AND COMPANY | 2004-08-17 | — | — | US | disclosed |
| EP-1153013-A2 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2001-11-14 | — | — | EP | disclosed |
| WO-2000047559-A2 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2000-08-17 | — | — | WO | disclosed |