Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 8/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.41 |
| ▸ | TUBB | P07437 | 2/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8794573 | 0.75 | ALOX15 (0.51) | ALOX15MAPTMAPK1MAP3K5ALDH1A1 | |
| SCHEMBL7074273 | 0.71 | MDM2 (0.40) | — | |
| SCHEMBL18584340 | 0.71 | MAP3K5 (0.56) | ALOX5MAPTMAPK1PDE3BPDE3A | |
| SCHEMBL7566334 | 0.71 | MAPT (0.53) | ALOX15MAPTMAPK1MAP3K5ALDH1A1 | |
| SCHEMBL9023820 | 0.70 | MAPT (0.46) | ALOX5MAPTMAPK1PDE3BPDE3A | |
| SCHEMBL7004935 | 0.70 | MAPT (0.44) | ALOX5PTGESALOX15MAPTALDH1A1 | |
| SCHEMBL7463695 | 0.70 | SLC6A2 (0.41) | MAPTMAPK1CYP1A2CYP2C19TUBB4A | |
| SCHEMBL5215529 | 0.69 | CCR2 (0.53) | MAPTSMN1; SMN2TSHR | |
| SCHEMBL7672077 | 0.69 | TUBB4A (0.67) | ALOX5ALOX15MAPTALDH1A1HPGD | |
| SCHEMBL18796672 | 0.69 | PDE3B (0.73) | ALOX5PTGESMAPTMAPK1PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173421-B1 | INDOLE DERIVATIVES AS ANTI-INFLAMMATION AGENTS | ASTRAZENECA AB (SE) | 2007-10-03 | — | — | EP | disclosed |