Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.43 |
| ▸ | HTR2A | P28223 | 4/20 | 0.43 |
| ▸ | HTR7 | P34969 | 4/20 | 0.43 |
| ▸ | HTR6 | P50406 | 4/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 5/20 | 0.38 |
| ▸ | HTR1A | P08908 | 4/20 | 0.37 |
| ▸ | DRD1 | P21728 | 4/20 | 0.37 |
| ▸ | DRD3 | P35462 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6067869 | 0.91 | DRD2 (0.41) | DRD2HTR2AHTR7HTR6NOS3 | |
| SCHEMBL499200 | 0.76 | NOS3 (0.62) | DRD2HTR2AHTR7HTR6NOS3 | |
| SCHEMBL5214087 | 0.73 | NOX1 (0.37) | DRD2HTR2AHTR7HTR6NOS3 | |
| SCHEMBL5216610 | 0.73 | MAPT (0.41) | MAPTNPC1RAB9ASIGMAR1ALDH1A1 | |
| SCHEMBL28783264 | 0.71 | CHRNB2 (0.41) | DRD2HTR2AHTR7HTR6NOS3 | |
| SCHEMBL2675396 | 0.71 | KCNH2 (0.57) | DRD2HTR2AHTR7HTR6NOS3 | |
| SCHEMBL2675587 | 0.70 | NOS3 (0.57) | DRD2HTR2AHTR7HTR6NOS3 | |
| SCHEMBL14208854 | 0.69 | KCNH2 (0.44) | DRD2HTR2AHTR7HTR6NOS3 | |
| SCHEMBL499337 | 0.69 | NOS3 (0.59) | DRD2HTR2AHTR7HTR6NOS3 | |
| SCHEMBL2674975 | 0.68 | NOS3 (0.58) | DRD2HTR2AHTR7HTR6NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539724-B1 | AMINO BENZOTHIAZOLE COMPOUNDS WITH NOS INHIBITORY ACTIVITY | NEURAXON INC (CA) | 2007-10-10 | — | — | EP | disclosed |