Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4409731 | 0.76 | IDO1 (0.33) | PPARAALDH1A1LMNA | |
| SCHEMBL4410124 | 0.70 | IDO1 (0.31) | — | |
| SCHEMBL28008711 | 0.66 | ALDH1A1 (0.46) | ALDH1A1LMNA | |
| Bicarbonate SCHEMBL9066694 | 0.64 | ALDH1A1 (0.58) | ALDH1A1LMNA | |
| SCHEMBL14193390 | 0.63 | NPC1 (0.51) | PPARAALDH1A1LMNA | |
| SCHEMBL10243854 | 0.62 | ALDH1A1 (0.61) | ALDH1A1LMNA | |
| SCHEMBL11725850 | 0.62 | LTA4H (0.43) | PPARAALDH1A1PRKCAPRKCD | |
| SCHEMBL620071 | 0.61 | CA1 (0.53) | ALDH1A1LMNA | |
| SCHEMBL25801955 | 0.61 | PAM (0.52) | ALDH1A1LMNA | |
| SCHEMBL29291372 | 0.61 | TSHR (0.46) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812017-A2 | OPHTHAMOLOGICAL DRUGS | Duke University (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006047466-A2 | OPHTHAMOLOGICAL DRUGS | DUKE UNIVERSITY (US) | 2006-05-04 | — | — | WO | disclosed |