Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 14/20 | 0.48 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5216687 | 0.92 | HTR4 (0.48) | HTR4NCF1KDM4ECYP1A2CYP2D6 | |
| SCHEMBL5215771 | 0.90 | HTR4 (0.47) | HTR4NCF1KDM4ECYP1A2CYP2D6 | |
| SCHEMBL5212310 | 0.89 | NCF1 (0.49) | HTR4NCF1 | |
| SCHEMBL5219363 | 0.85 | HTR4 (0.48) | HTR4NCF1MAPT | |
| SCHEMBL5218999 | 0.84 | HTR4 (0.49) | HTR4NCF1 | |
| SCHEMBL5214688 | 0.83 | HTR4 (0.48) | HTR4NCF1 | |
| SCHEMBL5306266 | 0.82 | HTR4 (0.47) | HTR4NCF1 | |
| SCHEMBL5215957 | 0.81 | SMN1; SMN2 (0.60) | HTR4MAPT | |
| SCHEMBL5214555 | 0.79 | HTR4 (0.41) | HTR4NCF1 | |
| SCHEMBL5215119 | 0.77 | HTR4 (0.44) | HTR4NCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1112270-B1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | claimed |